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40 compounds · from $17.99

Slimmaxxing — GLP-1, GIP & Triple-Agonist Compounds

Slimmaxxing is the shelf people arrive here for, and it splits cleanly in two. The incretin half is the familiar one: Semaglutide, the GLP-1 monoagonist behind Ozempic and Wegovy; Tirzepatide, which adds GIP receptor activity; and Retatrutide, the triagonist that layers glucagon receptor activation on top of both. Cagrilintide sits slightly apart as an amylin analogue, engaging a satiety pathway that runs parallel to GLP-1 rather than overlapping it, which is why the two get co-formulated. The non-incretin half is where the harder-to-find compounds live — 5-Amino-1MQ as an oral NNMT inhibitor, BAM-15 as a mitochondrial uncoupler, SLU-PP-332 as an ERR agonist, plus AOD9604, Adipotide and Tesofensine. Everything below is priced from the single supplier we verify against, with an HPLC certificate on every vial.

How the Three Incretin Tiers Differ

The gap between the three headline compounds is receptor count, and the trial data tracks it almost linearly. Semaglutide hits GLP-1 alone and recorded −14.9% mean body weight over 68 weeks in STEP 1. Tirzepatide adds GIP receptor agonism, which improves insulin-stimulated glucose uptake in adipose tissue and appears to blunt some of the GI burden — SURMOUNT-1 put it at −20.9% over 72 weeks. Retatrutide adds glucagon receptor activation on top of both, and that third receptor is an energy-expenditure mechanism rather than an appetite one: hepatic beta-oxidation and brown adipose thermogenesis. Its Phase 2 result of −28.7% at 48 weeks had not plateaued when the trial ended.

Why Escalation Schedules Are Not Optional

Every compound on this shelf that touches the GLP-1 receptor slows gastric emptying, and that is the direct cause of the nausea and motility complaints that show up in the first weeks. The standard answer is a four-week step schedule from the minimum effective dose, which is what the STEP, SURMOUNT and Retatrutide Phase 2 protocols all used. Skipping steps does not change where you end up, only how rough the trip is — adverse event rates climb sharply without the adaptation window. This is also why BPC-157 is the single most common add-on for anyone running a compound from this shelf.

The Non-Incretin Outliers

Not everything here works through appetite. 5-Amino-1MQ inhibits nicotinamide N-methyltransferase to raise intracellular NAD+ and reduce triglyceride accumulation in adipocytes, and it ships as an oral capsule rather than an injectable. BAM-15 is a mitochondrial protonophore — it uncouples oxidative phosphorylation so energy dissipates as heat instead of being stored. SLU-PP-332 activates estrogen-related receptors to mimic aspects of the exercise response. These are earlier-stage compounds with thinner evidence than the incretins, and they belong in a protocol as adjuncts, not substitutes.